Protein Modification Reagents
Medchemexpress LLC M-PEG-C1-DSPE sodium | 1000 | 1 G
m-PEG-C1-DSPE sodium is a structural analog of m-PEG-DSPE sodium (HY-W440922). It is a PEG lipid that can improve the delivery efficiency and tissue specificity of poorly soluble drugs. This product can be used in drug delivery research.
- Improve the delivery efficiency of poorly soluble drugs
- Improve the tissue specificity of poorly soluble drugs
- Suitable for drug delivery research
Medchemexpress LLC Cl-C6-PEG4-O-CH2COOH | 1799506-30-1 | 98.0% | 370.87 | 1 G
Cl-C6-PEG4-O-CH2COOH is a PEG-based PROTAC linker designed for the synthesis of chloroalkane-containing PROTACs (HaloPROTACs). This linker facilitates the formation of PROTACs, which are molecules that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker.
- Used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs).
- Facilitates PROTACs with two ligands for E3 ubiquitin ligase and target protein.
- Exploits the intracellular ubiquitin-proteasome system.
- Selectively degrades target proteins.
![eMolecules 14-(Azide-PEG5-ethylcarbamoyl)tridecanoic t-butyl ester | Broadpharm |602.814 | C30H58N4O8 | 98.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784454986](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502473327.JPG-250.jpg)
eMolecules 14-(Azide-PEG5-ethylcarbamoyl)tridecanoic t-butyl ester | Broadpharm |602.814 | C30H58N4O8 | 98.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784454986
14-(Azide-PEG5-ethylcarbamoyl)tridecanoic t-butyl ester | Broadpharm |602.814 | C30H58N4O8 | 98.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784454986
(=O)OCCNC(=O)OCCOCC(O)=O)OC(=O)CCCCCCCCCCCCCCCCC | 500mg | 713700078](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502475004.JPG-250.jpg)
eMolecules 2665069-75-8 | DSPE-PEG-CH2COOH, MW 3,400 | Broadpharm894.178 | C46H88NO13P | 95.000 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCNC(=O)OCCOCC(O)=O)OC(=O)CCCCCCCCCCCCCCCCC | 500mg | 713700078
DSPE-PEG-CH2COOH, MW 3,400 | Broadpharm | 2665069-75-8894.178 | C46H88NO13P | 95.000 | CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCNC(=O)OCCOCC(O)=O)OC(=O)CCCCCCCCCCCCCCCCC | 500mg | 713700078
Medchemexpress LLC Mal-amido-PEG24-acid | 2171095-70-6 | 98.5% | C58H108N2O29 | 25 MG
Mal-amido-PEG24-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. These molecules contain two different ligands connected by a linker; one targets an E3 ubiquitin ligase, and the other targets a specific protein, leveraging the intracellular ubiquitin-proteasome system for selective protein degradation.
- Peg-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Enables selective degradation of target proteins
- Intended for research use only
Cayman Chemical DPPE-MPEG 2000 50mg
A PEGylated form of DPPE; has been used in the synthesis of anionic liposomes for drug redistribution and toxicity prevention
Cayman Chemical PomalIdomIde 4alkylC6amIn 50mg
A PROTAC building block; has been used in the synthesis of PROTACs that drive HDAC8 degradation
Medchemexpress LLC Azide-PEG4-VC-PAB-doxorubicin | 99.6% | 1222.25 g/mol | C57H75N9O21 | 10 MG
Azide-PEG4-VC-PAB-doxorubicin is a drug-linker conjugate used in antibody-drug conjugate research and click-chemistry bioconjugation.
- Contains an azide functional group for click chemistry.
- Valine-citrulline peptide linker with a PAB self-immolative spacer.
- Molecular weight 1222.25 g/mol.
- Chemical formula C57H75N9O21.
- Purity 99.6%.
- Pack size includes 10 mg solid and other sizes.
- Appearance orange to red solid.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC VH285-PEG4-C4-Cl (HaloPROTAC 3) | 1799506-07-2 | ≥98.0% | 799.42 | 10 MG
VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and a 16-atom-length linker, with a Halogen group as the connector of the linker. It incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. It is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM, and can induce 90% degradation of GFP-Halotag at 625 nM. It binds to VHL with an IC50 of 0.54 μM.
- Conjugate of ligands for E3 and a 16-atom-length linker.
- Connector of linker is a Halogen group.
- Incorporates VHL ligand and an alkyl/ether-based linker.
- Highly potent and efficacious degrader of GFP-HaloTag7 (DC50 of 19 nM).
- Able to induce 90% degradation of GFP-Halotag at 625 nM.
- Binds to VHL with an IC50 of 0.54 μM.
![eMolecules Cy5-PEG5-NHBoc | BroadpharmMFCD28142459 | 881.590 | C49H73ClN4O8 | 96.000 | [Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 10mg | 263744685](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502477655.JPG-250.jpg)
eMolecules Cy5-PEG5-NHBoc | BroadpharmMFCD28142459 | 881.590 | C49H73ClN4O8 | 96.000 | [Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 10mg | 263744685
Cy5-PEG5-NHBoc | BroadpharmMFCD28142459 | 881.590 | C49H73ClN4O8 | 96.000 | [Cl-].CN1\C(=C\C=C\C=C\C2=[N+](CCCCCC(=O)NCCOCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12 | 10mg | 263744685
Medchemexpress LLC DBCO-β-Glu-PEG12-Exatecan | 3025107-83-6 | 98.6% | 1833.95 | 1 MG
DBCO-β-Glu-PEG12-Exatecan is an inhibitor for topoisomerase I and can be utilized as a Drug-Linker Conjugate for ADC molecules.
- Inhibitor for topoisomerase I
- Drug-Linker Conjugate for ADC molecules
- Purity of 98.63%
- Solid appearance, off-white to light yellow color
- Recommended storage at -20°C (sealed, away from moisture and light)
- Extended storage in solvent at -80°C for 6 months, or -20°C for 1 month
eMolecules 77544-68-4 | PEG4-Tos | Broadpharm | MFCD18433414 | 304.360 | C13H20O6S | 96.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCO | 5g | 112541250
PEG4-Tos | Broadpharm | 77544-68-4 | MFCD18433414 | 304.360 | C13H20O6S | 96.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCO | 5g | 112541250
Medchemexpress LLC Mal-amido-PEG2-NHS ester | 955094-26-5 | MFCD11041137 | 99.3% | 425.39 | C18H23N3O9 | 100 MG
Mal-amido-PEG2-NHS ester is a noncleavable ADC linker containing a maleimide group and an N-hydroxysuccinimide (NHS) ester separated by a two-unit polyethylene glycol (PEG2) spacer. It is used for bioconjugation, enabling thiol- and amine-specific coupling for antibody-drug conjugates and labeling applications.
- Noncleavable ADC linker with maleimide and NHS ester functionalities.
- Maleimide reacts with thiol groups for site-specific conjugation.
- NHS ester labels primary amines on proteins and amine-modified oligonucleotides.
- PEG2 spacer increases hydrophilicity and aqueous solubility.
- High purity suitable for research bioconjugation applications.
Medchemexpress LLC Mal-PEG2-VCP-Eribulin | 2130869-18-8 | 99.8% | 1374.57 | 5 MG
Mal-PEG2-VCP-Eribulin is a drug-linker conjugate for ADCs, combining an ADCs linker (Mal-PEG2-VCP) with Eribulin. Eribulin is a mechanistically unique microtubule inhibitor that inhibits the proliferation of cancer cells by binding to microtubule proteins and microtubules. This Eribulin-based agent is designed for antibody conjugates and is intended for research use only.
- Drug-linker conjugate for ADCs
- Contains ADCs linker (Mal-PEG2-VCP)
- Incorporates Eribulin, a microtubule inhibitor
- Inhibits cancer cell proliferation
- Suitable for antibody conjugates
- For research use only
Medchemexpress LLC M-PEG-C1-DSPE sodium | 1000 | 100 MG
m-PEG-C1-DSPE sodium (MW 1000) is a PEG lipid, serving as a structural analog to m-PEG-DSPE sodium (MW 1000). This compound is valuable in drug delivery research, particularly for improving the efficiency and tissue-specific delivery of drugs that are poorly soluble.
- Enhances delivery efficiency of poorly soluble drugs.
- Improves tissue specificity for drug targeting.
- Suitable for various drug delivery research applications.